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Creative Biolabs Woos Researchers with Full Complement-related Customized Services

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Creative Biolabs Woos Researchers with Full Complement-related Customized Services

August 12
16:16 2021
Increasingly new insights and emerging treatments based on the complement system have encouraged Creative Biolabs, a leading CRO in complement therapeutics discovery, to enrich services customized for research based on different complement pathways and effectors.

New York, USA – August 12, 2021 – Consisting of distinct heat-labile plasma proteins that influence each other in a catalytic cascade, the complement system can rapidly and specifically detect, trace, target, and destroy pathogens as well as fight infection. Researchers have addressed the importance of the complement system and achieved significant advancement in various diseases, including COVID-19, coronary artery disease, and transplant-associated thrombotic microangiopathy.

Having contributed to complement therapeutic research for years, Creative Biolabs leverages its one-stop drug discovery platforms to enable the development of research tools, therapeutic candidates, and diagnostic reagents for the complement system, as well as a full range of services.

Services for Membrane Attack Complex (MAC)

Membrane attack complex, a form of the terminal complement complex (TCC), is a stable multiprotein complex that is composed of complement components C5b, C6, C7, C8, and C9. MAC induces cytolysis and mediates irreversible target cell membrane damage to foreign microorganisms, viruses, fungi, damaged erythrocytes, and nucleated cells by increasing the membrane permeability. Thoroughly understanding different features of MAC, Creative Biolabs proposes tailored services based on the membrane attack complex to support C6, C7, C8, and C9 targeted complement therapeutic subjects.

Services for Complement Pathways

Proportionate activation of the complement system is critical, in that overactivation could lead to thromboinflammation and end-organ damages while complement deficiency exposures the body to life-threatening infections. Since the complement activation majorly involves classical, lectin, and alternative pathways which converge to the formation of C3 convertase, Creative Biolabs covers comprehensive customized services for these three main complement pathways.

The Classical Pathway Targets

The classical complement pathway is activated by the direct association of C1q with pathogen surfaces or the binding of C1q to antigen-antibody complexes in adaptive immune responses. Services based on the classical pathway targets, such as C1 complex, C1 Inhibitor, C2, C3, C4, C5, and C5aR can be reached at Creative Biolabs.

The Lectin Pathway Targets

The lectin complement pathway, or known as the mannose-binding lectin (MBL) pathway, is triggered by the binding of MBL to mannose that contains carbohydrate structures on bacteria or virus surfaces. To support studies leveraging its ability to elicit various effector functions like phagocytosis and cell lysis, Creative Biolabs devotes itself to customizing services related to the lectin pathway targets, including development services for MBL-associated serine proteases 1 and MBL-associated serine proteases 2.

The Alternative Pathway

The alternative complement pathway is activated once the spontaneously activated complement C3 protein (C3b fragment) binds to the pathogen’s surface. Creative Biolabs has satisfied numerous clients with a full range of complement therapeutic antibodies, inhibitors, soluble complement regulators, reagents, and services related to the alternative pathway.

About Creative Biolabs

As a professional CRO, Creative Biolabs focuses on developing first-in-class and potent complement antibodies, inhibitors, soluble complement regulators, aptamers, etc. and provides customized services for complement research.

For more complement services and products, please visit https://www.creative-biolabs.com/complement-therapeutics.

Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States
Website: https://www.creative-biolabs.com/complement-therapeutics